PASADENA, California – For all you moonshine makers who thought your hobby was just a guilty pleasure, a new spin on distilling may actually help save lives. Using ancient technology reduced to a microscopic scale, scientists at Caltech have created new tools to detect disease and purify water using tiny stills.The creation of the still around A.D. 500 was one of humanity's earliest, and still quite popular, technological advancements. Traditionally, a still boils liquids in order to vaporize and separate them. Now, using nanoparticles and lasers, liquids no longer need to be boiled to be separated.Removing the heat requirement from distillation means the process could be used to separate living cells without killing them, which could lead to advanced disease detection. Other applications include extracting water cheaply and efficiently from sea water in low-energy saltwater distillation plants. How do they do it Take a tour through professor David Boyd's lab and go behind the scenes of this revolutionary process.Left: A green laser evaporates the water from a liquid. This is the final stage of nano distillation. Here is a diagram of the basic nano still technique. At top is the initial setup with gold nanoparticles sitting on top of a glass slide. The fluid waiting to be distilled is enclosed from above by a silicone rubber chip.In the bottom diagram, a green laser operating near the resonant frequency of the gold particles is applied. The laser heats the gold nanoparticles, which then transfer the heat to the surrounding fluid. This small amount of heat is just enough to cause controlled evaporation over the gas bubble barrier, leaving pure water on the right-hand side of the diagram.Click through to the next photo to take a closer look at each of these steps.Illustration: Chemical Separations by Bubble Assisted Interphase Mass-Transfer, David A. Boyd, James Adelman, David Goodwin, and Demetri PsaltisThis spin coater is used to spread out the thin layer of gold nanoparticles on the glass slide. A drop of the gold solution is placed on the slide and the coater spins extremely fast. This spinning spreads the solution evenly and coats the slide with a nearly uniform 15-nanometer layer of gold. To get a controlled spacing of particles there needs to be a structure in place to hold them. To achieve this, scientists add a polymer to the gold solution. This polymer forms a uniform lattice to structure all the gold. But observant readers will notice there was no polymer in the previous diagram. Where does it go Click to the next photo to find out.This is an oxygen etcher. Once the glass slide is covered with the polymer-and-gold solution, this etcher burns off the polymer, leaving just the gold behind. This is a sample slide covered with a matrix of gold nanoparticles. The purple streaks on the slide are the nanoparticles, visibly spreading out from the initial drop applied to the slide during the spin coating. For those readers expecting the entire slide to be purple, scientists actually need only a small portion of the slide to be covered uniformly by the gold, so these streaks will suffice. The particles have a unique property of rapidly dissipating heat, which is a key factor in how the still works.In another part of the lab, the piece of silicone rubber is made. If you think back to the second image in this gallery, you'll recall that the silicone rubber encloses the fluid between itself and the glass slide. This piece of silicone is called the microfluidic chip because of the fluid channels carved into it. The machine pictured at left is called a mask aligner. It creates a mold for the microfluidic chip. It does this by exposing an image in this case, the shape and design of the chip to a photosensitive material. The unexposed portion of the material is discarded, and the shape of the mold is all that's left. It's similar to a photo enlarger, but instead of a two-dimensional image, a fully formed nano structure is made. The final mold is then used to create fluid channels in a piece of silicone rubber. This silicone rubber ends up being the microfluidic chip.Here, the silicone rubber chip is drilled to create ports for the nano still. These ports will be used to inject solutions for distillation and to extract the distilled liquid.Tiny plugs of silicone are the doughnut holes of the micro-fabrication world. Sadly, these plugs will remain uneaten.After fabrication of the microfluidic chip, we're ready to put it all together. The chip is glued to the gold-coated slide that we made earlier pictured at center-left inside petri dish. Now we have a nano still, which has an electronic sensor attached for measuring the conductivity of the fluid.Sometimes science is messy. This workbench is covered with a collection of syringes and gold nanoparticle-coated glass slides. The syringes are used to inject fluids through the ports into the channels in the still, which we'll see in the next photo.In this photo, blue "Smurf blood" food-grade dye is injected into the nano still through a syringe. The dye makes it easy to see when the liquid has been distilled. The distilled water will be clear and the remaining water will become darker due to the higher concentration of dye.A low-powered green diode laser shines down into the still. The laser is roughly the same strength as an off-the-shelf laser pointer. Very little energy is needed in the microdistilling process thanks to the heat-dissipating properties of the gold nanoparticles.Professor Boyd, the lead researcher on the project, reveals that this process was largely discovered by accident. "We had this problem with an air bubble, so we started hitting it with a laser. Instead of getting rid of it, we saw that we were actually causing the distillation process to occur, which was completely unexpected," Boyd explains.